Peptides Therapy in Naples
CJC 1295 / Ipamorelin combination available
CJC 1295 - CJC 1295 stimulates growth hormone secretion and will keep a steady increase of HGH and IGF-1 with no increase in prolactin, leading to fat loss, and increased protein synthesis thereby promoting growth.
CJC 1295 is a tetrasubstituted 29-amino acid peptide hormone, primarily functioning as a growth hormone releasing hormone (GHRH) analog. CJC 1295 out performs the older and outdated GHRH, Sermorelin. The half-life of Sermorelin ranges from 8-12 minutes, whereas the half-life of CJC 1295 extends to 30 minutes. Sermorelin’s efficacy decreases with time and the body produces antibodies to Sermorelin, bioconjugate with serum albumin, thus increasing its half-life and potential therapeutic window. It accomplishes this by using protecting groups around the amino acids of GHRH typically susceptible to enzymatic degradation, thus increasing the half-life. Consequently CJC 129 without DAC is designed to provide a GHRH-like stimulation around the clock with increased amplitude and longer stimulation, (28 minutes instead of 8-12 of sermorelin), maintaining the natural pulsatile stimulation of the pituitary without decreasing secretion as observed in CJC with DAC.
CJC 1295 has been shown to increase growth hormone as well as IGF-I secretion and it has been able to do so in very large amounts. CJC 1295 stimulates growth hormone secretion and will keep a steady increase of HGH and IGF-1 with no increase in prolactin, leading to fat loss, and increased protein synthesis thereby promoting growth.
Ipamorelin is a selective GH-Secretagogue and ghrelin receptor agonist. The potency of ghrelin stimulation can be compared to GHRP6 with less appetite stimulation properties. However, unlike other GH-Secretagogues this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin and aldosterone. It is for this reason Ipamorelin has been considered the first selective GH Secretagogue.
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate healing of many different wounds, especially bone to tendonand superior healing of damaged ligaments.
In addition, BPC 157 seems to protect organs and to prevent ulcers of the stomach. BPC-157 acts systemically in the digestive tract to combat leaky gut, IBS, cramps, and crohn’s disease.
This peptide has been shown to decrease damage in effected areas. Those who suffer with discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues.
Ibutamoren / MK677
MK-677 is a long active orally bioactive agonist of the GHS-R1a. As such, binds to the same receptor that GHRP2, GHRP6, and Ipamorelin also stimulate. Also called Ibutamoren, it has shown to cause a predictable rise in IGF-1 but unlike other GH secretagogues doesn’t help to decrease adipose tissue. It has been shown to increase lean muscle mass and might be a good candidate for sarcopenic patients with low bone mineral density. In order to reduce the negative effect of somatostatin, MK-677 is best taken on an empty stomach with no insulin in the system.
IGF 1 LR3 – Insulin Like Growth Factor LR3
IGF-1 is a small peptide consisting of 70 amino acids with a molecular weight of 7649 Da. IGF-1 has an A and B chain connect- ed by disulphide bonds, like insulin, which is how it got its' name. The structural similarity to insulin explains the ability of IGF-1 to bind (with low affinity) to the insulin receptor. IGF-1 is secreted by many tissues and the secretory site seems to determine its actions. Most IGF-1 is secreted by the liver and is transported to other tissues, acting as an endocrine hormone. IGF-1 is also secreted by other tissues, including cartilagenous cells, and acts locally as a paracrine hormone.
Most of the IGF-1 produced by the liver is secreted for its proliferative and growth effects. Lower IGF-1 and growth hormone are often associated with excess body fat. IGF-1 and other proteins in the IGF family are growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue. IGF-1 plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is commercially available and is used for the treatment of growth failure. Therapeutic administration of IGF-1 is associated with reversing insulin sensitivity, reducing weight and increasing metabolic expenditure as well potential reversal of degeneration of spinal cord motor neuron axons in certain peripheral neuropathies.
IGF-1 LR3 has a modified amino acid sequence compared to biological IGF-1. It has a additionally arginine at amino acid position 2. By making this change, it gives the molecule higher potency and a much longer half-life. For this reason it is commonly used as long acting version for the same therapuetic reasons as the IGF-1.
GHK / Cu
GHK-Cu is a naturally occurring copper complex that was first identified in human plasma, but has hence been found in multiple locations such as saliva and urine. Copper peptides are small, naturally occurring protein fragments that have high affinity for copper ions, which are critical to normal body function. GHK-Cu has a variety of roles in the human body including, but not limited to, promoting activation of wound healing, attracting immune cells, antioxidant and anti-inflammatory effects, stimulating collagen and glycosaminoglycan synthesis in skin fibroblasts, and promoting blood vessel growth. There has been evidence that has shown that it acts as a feedback signal that is generated after tissue injury. First, it seems to act as a potent protector of tissue and anti-inflammatory agent that controls the oxidative damage that occurs post-tissue injury. Further, it then plays a big role in signaling tissue remodeling which removes damaged/scarred tissue and generates new, healthy tissue. However, these positive effects decline with age because the concentration of GHK-Cu in the body decreases with age. Thus, there is an increase in inflammation, cancerous activity, and tissue destruction.
Bremelanotide / PT 141
Bremelanotide was developed from the peptide hormone Melanotan II. In initial testing, Melanotan II induced darkening of skin pigment but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects (Ref: Uni of Arizona Dr Hunter Wells) Further testing in animals showed Bremelanotide to induce lordosis (a sexual mating behavior) and subsequently tested for its effect in humans. Although, most of the research has been targeted to women with female sexual dysfunction an effective medication in treating sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire via the nervous system.
It is estimated that 43% of women (30 million in the US) suffere from female sexual dysfunction and 30 million men suffer from ED, with the incidence increasing by as much as 3 fold as we age. Bremelanotide has NO Contraindications and is effective in people who don’t respond to Viagra or Cialis.
SARMS / LGD 4033
Selective Androgen Receptor Modulators (SARMs) provide the benefits of traditional anabolic/androgenic steroids such as testosterone (including increased muscle mass, fat loss, and bone density), while having a lower unwanted side effects of (aromatization / increased DHT).
By stimulating the androgen receptor, SARMs can provide a similar therapeutic outcome to androgen therapy without any increase in androgen levels. SARMs have the potential to take the place of the androgens, and therefore exert many of the same positive effects on muscle tissue. SARMs can be administered in an injectable dosage form and are absorbed orally are not liver toxic like most oral steroids are. The anabolic effect has been measured to be roughly the same or greater than testosterone. It has also been shown to produce dose-dependent increases in bone mineral density and mechanical strength decrease body fat and increase lean body mass.
LGD-4033 is a relatively new SARM on the market. It can be dosed orally at low doses and has a very strong anabolic effect.
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